An Alternative DNA Endonuclease Activity is Associated with the LINE-1 ORF2-encoded Protein
Mitsuhiro Nakamura, Huira C. Kopera, Mark Dowling, O. Barábas, John V. Moran
The paper identifies an alternative endonuclease activity in L1 ORF2p that enables EN-independent retrotransposition.
bioRxiv · Jan 20, 2026 · PreprintMolecular Biology