Author

Huira C. Kopera

University of MichiganORCID 0000-0002-8347-5567Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Cancer Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Assay:DNA methylation· 1 Assay:proteomics· 1 Research Focus:variant calling· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

John V. MoraniD· 3 shared Jeffrey M. KiddiD· 2 shared John B. MoldovaniD· 2 shared Aitor Serres Amero· 1 shared Alexander Eckehart UrbaniD· 1 shared Alexej S. AbyzoviD· 1 shared Alice Lee· 1 shared Alison R. BartoniD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersMolecular Biology

John V. MoranORCID

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Author profile →

4 papers

Recent·Most cited

An Alternative DNA Endonuclease Activity is Associated with the LINE-1 ORF2-encoded Protein

Mitsuhiro Nakamura, Huira C. Kopera, Mark Dowling, O. Barábas, John V. Moran

The paper identifies an alternative endonuclease activity in L1 ORF2p that enables EN-independent retrotransposition.

bioRxiv · Jan 20, 2026 · PreprintMolecular Biology

Splicing of HPV16 E6 promotes aggressive invasion in oropharyngeal cancer via redistriburion of E-cadherin

Yvonne Xinyi Lim, Min Liu, Bailey Fabiny Garb, Allison Kate Cullen Furgal, Shiting Li, Shaomiao Xia, Andrew Whiteman, Junsouk Choi, Qingzhi Liu, Huira C. Kopera, Roland Hilgarth, Marcell Costa de Medeiros, Laura Gonzalez-Maldonado, Thomas M. Lanigan, Jonathan Mchugh, , Nisha J. D’Silva

This study shows that HPV16 E6 splicing variants influence oropharyngeal cancer aggressiveness by altering E-cadherin localization and clinical outcomes.

bioRxiv · Oct 16, 2025 · PreprintCancer Biology

Variable patterns of retrotransposition in different HeLa strains provide mechanistic insights into SINE RNA mobilization processes

John B. Moldovan, Huira C. Kopera, Ying Liu, Marta García-Cañadas, Purificación Catalina, Paola Leone, Laura Sánchez, Jacob Otto Kitzman, Jeffrey M. Kidd, Jose Luis Garcia-Perez, John V. Moran

The paper shows HeLa strains differ in Alu retrotransposition efficiency, with distinct mechanisms for SINE RNA mobilization involving ORF2p.

Nucleic Acids Research · May 14, 2024Peer-reviewedMolecular Biology

DeepMosaic: Control-independent mosaic single nucleotide variant detection using deep convolutional neural networks

Xiaoxu Yang, Xin Xu, Martin W. Breuss, Danny Antaki, Laurel Ball, Changuk Chung, Jiawei Shen, Chen Li, Renee D. George, Yifan Wang, Taejeong Bae, Yuhe Cheng, Alexej S. Abyzov, Liping Wei, Ludmil B. Alexandrov, , Sarah B. Emery

DeepMosaic detects mosaic single nucleotide variants without control samples using deep convolutional neural networks, achieving high accuracy and uncovering many variants missed by existing methods.

Nature Biotechnology · Jan 2, 2023Peer-reviewedGenomics