Identification of a pharmacokinetic interaction between teicoplanin and sulfo-butyl ether-beta-cyclodextrin, an excipient in the intravenous posaconazole formulation
Yoshimasa Adachi, Mitsuhiro Sugimoto, Yusei Yamada, Junya Kanda, Atsushi Yonezawa, Takeo Yamagiwa, Yuta Hanyu, Mizuki Watanabe, Yasuyuki Arai, Chisaki Mizumoto, Toshio Kitawaki, Tadakazu Kondo, Kouhei Yamashita, Natsuki Imayoshi, Yuki Shigetsura, , Tomohiro Terada
The paper identifies a pharmacokinetic interaction between teicoplanin and SBECD, an excipient in posaconazole, showing reduced TEIC protein binding and increased renal excretion in rats and patients.
bioRxiv · Mar 13, 2026 · PreprintPharmacology & Toxicology