Akifumi Takaori‐Kondo

This study identifies 16 AML subgroups based on chromatin accessibility profiles using ATAC-seq in 1,563 cases, revealing epigenetic heterogeneity and its clinical and therapeutic implications.

The paper identifies a pharmacokinetic interaction between teicoplanin and SBECD, an excipient in posaconazole, showing reduced TEIC protein binding and increased renal excretion in rats and patients.

This study identifies the non-spike R204P mutation in the SARS-CoV-2 Omicron XEC variant as a driver of increased inflammation and pathogenicity through NF-κB activation.

The paper develops a single-cell transcriptomic map of cynomolgus macaque hematopoietic stem cells and progenitors, revealing molecular differences from humans and a direct differentiation pathway to megakaryocyte lineages.

The paper shows that myeloid-biased hematopoiesis in aging is due to altered LT-HSC/ST-HSC ratios, not HSC clone heterogeneity.

The paper presents nine alpaca nanobodies that recognize conserved hidden epitopes on SARS-CoV-2 spike proteins across variants and maintain neutralizing activity against escape mutations.

The paper examines SLFN11 expression in B-cell development and lymphomas, finding it is epigenetically suppressed in germinal center B cells and that epigenetic modifiers enhance its expression, increasing sensitivity to cytosine arabinoside.

The paper examines TP53 allelic states in MDS patients, finding that bi-allelic targeting is linked to worse outcomes, while mono-allelic targeting does not differ from wild-type patients.

The paper develops NET-CAGE to detect nascent RNA 5-ends, identifies enhancer-promoter pairs, and reveals topological connections of cis-regulatory elements across cell types.