MALDI-TOF imaging mass spectrometry demonstrates sex- and age-dependent spatial changes in brain energy metabolism in response to amyloid stress using a mouse model of Alzheimers Disease
Sandra Grahovac-Nemeth, Kristina Jurčić, Marc Courchesne, Karen L. Nygard, Grace Callahan, Ariel K. Frame, Reza Khazaee, Wenxuan Wang, Moganatharsa Ganeshalingam, Raymond Thomas, Shawn Narain Whitehead, Robert C. Cumming
The paper uses MALDI-TOF imaging to show sex- and age-dependent changes in brain metabolites and histone lactylation in a mouse Alzheimer's model, linking them to metabolic-epigenetic coupling and sex-specific AD vulnerability.
bioRxiv · Sep 21, 2026 · PreprintNeuroscience