Author

Karen L. Nygard

Western UniversityORCID 0000-0002-2203-4530Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Assay:imaging· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:mouse· 1 Organism:rat· 1 Research Focus:spatial domain detection· 1 Approach:statistical model· 1

Frequent Co-Authors

Shawn Narain WhiteheadiD· 2 shared Ariel K. FrameiD· 1 shared Bryan S. RichardsoniD· 1 shared Grace Callahan· 1 shared Kristina Jurčić· 1 shared Marc C.J. CourchesneiD· 1 shared Marc Courchesne· 1 shared Moganatharsa Ganeshalingam· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersNeuroscience

Shawn Narain WhiteheadORCID

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2 papers

Recent·Most cited

MALDI-TOF imaging mass spectrometry demonstrates sex- and age-dependent spatial changes in brain energy metabolism in response to amyloid stress using a mouse model of Alzheimers Disease

Sandra Grahovac-Nemeth, Kristina Jurčić, Marc Courchesne, Karen L. Nygard, Grace Callahan, Ariel K. Frame, Reza Khazaee, Wenxuan Wang, Moganatharsa Ganeshalingam, Raymond Thomas, Shawn Narain Whitehead, Robert C. Cumming

The paper uses MALDI-TOF imaging to show sex- and age-dependent changes in brain metabolites and histone lactylation in a mouse Alzheimer's model, linking them to metabolic-epigenetic coupling and sex-specific AD vulnerability.

bioRxiv · Sep 21, 2026 · PreprintNeuroscience

White matter microglia morphological changes with aging in guinea pig offspring born growth restricted

Timothy B. Nunes, Karen L. Nygard, Marc C.J. Courchesne, Shawn Narain Whitehead, Bryan S. Richardson, Timothy R.H. Regnault

The paper examines white matter microglial morphology changes with aging in growth-restricted guinea pig offspring and finds no exacerbation of these changes compared to controls.

Canadian Journal of Physiology and Pharmacology · Apr 17, 2025Peer-reviewedDevelopmental Biology