Integrative multiomic analysis links TDP-43-driven splicing defects to cascading proteomic disruption of ALS/FTD pathways
Velina Kozareva, Zhengde Liu, Keyana L. Blake, Yue Andy Qi, Sasha Rollinson, Sahba Seddighi, Mohammad Alsaidi, Stanislav Tsitkov, Mercedes Prudencio, Leonard Petrucelli, Dennis W. Dickson, Anna‐Leigh Brown, Pietro Fratta, Hong Joo Kim, J. Paul Taylor, , Sarah E. Kargbo-Hill
The paper identifies TDP-43-dependent molecular cascades in ALS/FTD by integrating multiomic data from iPSC-derived neurons and validates key genes through experimental assays.
bioRxiv · Sep 29, 2025 · PreprintNeuroscience