Biophysical and Colloidal Properties Govern Anti-Drug Antibody Generation: A Case Study Using the Tumoricidal mAb 4713
Sanjida Yesmin, Mohammad Monirul Islam, Md. Din Islam, Hiromichi Tsurui, Tomonori Saotome, Shuji Matsuoka, Yutaka Kuroda
This study investigates how different stress conditions affect mAb 4713 aggregation and its potential to induce anti-drug antibodies in mice, finding that structural and colloidal properties of aggregates determine immunogenicity.
bioRxiv · Sep 3, 2025 · PreprintBiophysics