Thermodynamic Stability Modulates Chaperone-Mediated Disaggregation of α-Synuclein Fibrils
Celia Fricke, Antonín Kunka, Rasmus K. Norrild, Shuangyan Wang, Thi Lieu Dang, Jonas Folke, Mohammad Shahnawaz, Claudio A. Soto, Susana Aznar, Anne S. Wentink, Bernd Bukau, Alexander Kai Buell
This study shows that the thermodynamic stability of alpha-synuclein fibrils affects their disaggregation by the chaperone system HSP70, DNAJB1, and Apg2, with more stable fibrils being less efficiently disaggregated.
Chemical Science · Nov 11, 2025Peer-reviewedBiophysics