An axon-intrinsic loop restricts nerve regeneration through axonal protein synthesis
Courtney N. Buchanan, Jinyoung Lee, Samaneh Matoo, Jordan A. Headen, Marie-Claire Honoree, Molly Conway, Lillian F. Thompson, Terika P. Smith, Ansley McKay, Cailyn Tosadori, Irene Dalla Costa, Moira Lopez De Leon, Elizabeth L. Thames, Nora I. Perrone‐Bizzozero, Ashley L. Kalinski, , Jeffery L. Twiss
This study identifies an axon-intrinsic loop where REG3A promotes KHSRP translation, slowing nerve regeneration through localized mRNA synthesis and Ca2+ signaling.
Science Advances · Aug 26, 2026Peer-reviewedNeuroscience