Jeffery L. Twiss

Spatially Constrained Monte Carlo Permutation Test Reveals Diffusion Changes Near Stress Granules

The paper introduces SPaCe-MC, a statistical method to detect localized diffusion changes near stress granules, revealing consistent local constraints despite varied global cytoplasmic responses.

An axon-intrinsic loop restricts nerve regeneration through axonal protein synthesis

This study identifies an axon-intrinsic loop where REG3A promotes KHSRP translation, slowing nerve regeneration through localized mRNA synthesis and Ca2+ signaling.

Multiple mTOR RNA localization signals regulate subcellular protein synthesis and axonal growth

The paper identifies multiple mTOR RNA localization signals in the 5'UTR and 3'UTR that regulate subcellular mTOR localization, protein synthesis, and axonal growth in mice.

A mouse model of autosomal dominant spastic ataxia and myopathy caused by a mutation in Tuba4a

The paper describes a mouse model with a Tuba4a mutation causing spastic ataxia and myopathy, showing disease progression and specific neurological and muscular defects.

KHSRP-mediated Decay of Axonally Localized Prenyl-Cdc42 mRNA Slows Nerve Regeneration

The paper shows that KHSRP-mediated decay of axonal Prenyl-Cdc42 mRNA slows nerve regeneration by regulating mRNA stability and transport in response to growth signals.

Acetylation of Axonal G3BP1 through ELP3 Accelerates Axon Regeneration

This study shows that acetylation of G3BP1 by ELP3 promotes axon regeneration and neuronal recovery after injury.

Restoring DSCAM expression rescues neuronal morphology and axon guidance deficits in Down syndrome

Single Particle Tracking of Genetically Encoded Nanoparticles: Optimizing Expression for Cytoplasmic Diffusion Studies

This paper optimizes genetically encoded nanoparticle expression to improve single-particle tracking of cytoplasmic diffusion in mammalian cells, showing increased diffusivity and better tracking quality.

Targeted Polymersomes Enable Enhanced Delivery to Peripheral Nerves Post-Injury

This study shows that ApoE-tagged polymersomes retain more payload in injured nerves, while RVG-tagged polymersomes better penetrate nerves via intramuscular injection.

Disruption of G3BP1 Granules Promotes Mammalian CNS and PNS Axon Regeneration

This paper shows that disrupting G3BP1 granules promotes axon regeneration in both CNS and PNS injuries, suggesting a therapeutic strategy for neural repair.

Dynamic Effects of Ventral Hippocampal NRG3/ERBB4 Signaling on Nicotine Withdrawal-Induced Responses

This study investigates the role of NRG3-ERBB4 signaling in the ventral hippocampus during nicotine withdrawal, showing its impact on anxiety-like behaviors and synaptic function.

PTBP1 Regulates Injury Responses and Sensory Pathways in Adult Peripheral Neurons

This study shows PTBP1 is expressed in adult sensory and motor neurons, with increased axonal levels after injury, affecting axon outgrowth and sensation.

The Injured Sciatic Nerve Atlas (iSNAT), Insights into the Cellular and Molecular Basis of Neural Tissue Degeneration and Regeneration

The paper creates an atlas of injured sciatic nerve cells and identifies immune microenvironments and communication networks in mouse nerve regeneration.

Loss of KHSRP Increases Neuronal Growth and Synaptic Transmission and Alters Memory Consolidation Through RNA Stabilization

Intra-axonal translation of Khsrp mRNA slows axon regeneration by destabilizing localized mRNAs

This study identifies KHSRP as an axonal RNA-binding protein whose mRNA is locally translated after nerve injury, leading to mRNA destabilization and slowed axon regeneration.

Selective axonal translation of prenylated Cdc42 mRNA isoform supports axon growth

The paper shows that prenyl-Cdc42 mRNA localizes to PNS axons and promotes axon growth through localized translation and prenylation.

An essential post-developmental role for Lis1 in mice

This paper shows that Lis1 is essential for axonal transport in adult mice, with loss of Lis1 causing severe neurological symptoms and death.