The dichotomous impacts of semaphorin3E deficiency on exacerbating airway hyperresponsiveness, remodelling, and inflammation in type-2 low and type-2 high asthma models
Mojdeh Matloubi, Fatemeh Sedaghat, Lianyu Shan, Sujata Basu, Andrew J. Halayko, ABDELILAH SOUSSI GOUNNI
This study investigates the role of Sema3E in type-2 low and type-2 high asthma models, showing it exacerbates airway hyperresponsiveness and inflammation in type-2 low but promotes mucus production and eosinophilia in type-2 high asthma.
PLoS ONE · Jun 13, 2025Peer-reviewedImmunology