Andrew J. Halayko

Characterization of tri-culture alveolar-like organoids to study fibrotic lung diseases

This study develops a 3D tri-culture alveolar organoid model to investigate fibrotic lung disease responses to TGF-β and bleomycin, revealing distinct transcriptional changes and signaling pathways.

Human breast milk extracellular vesicles from mothers with asthma differentially modulate the release of inflammatory cytokines by primary human airway smooth muscle cells in a recipient-cell specific manner

This study shows that breast milk extracellular vesicles from mothers with asthma differentially modulate cytokine release by airway smooth muscle cells depending on the donor and recipient cell type.

The dichotomous impacts of semaphorin3E deficiency on exacerbating airway hyperresponsiveness, remodelling, and inflammation in type-2 low and type-2 high asthma models

This study investigates the role of Sema3E in type-2 low and type-2 high asthma models, showing it exacerbates airway hyperresponsiveness and inflammation in type-2 low but promotes mucus production and eosinophilia in type-2 high asthma.

Novel DNA methylation changes in mouse lungs associated with heavy smoking

This study identifies 32 differentially methylated genes in mouse lungs associated with heavy smoking, revealing novel links to nicotine dependency, tumorigenesis, and COPD.

Early life exposure to cigarette smoke primes lung function changes and DNA methylation changes at Cyp1a1 upon exposure later in life

This study shows that prenatal and early postnatal cigarette smoke exposure in mice leads to long-term lung function and DNA methylation changes at Cyp1a1, which can be reestablished upon adult re-exposure.

Differentiation of airway cholinergic neurons from human pluripotent stem cells for airway neurobiology studies

This paper develops an in vitro model of human airway cholinergic neurons from pluripotent stem cells to study neuroplasticity in respiratory diseases.

Integrating Proteomes for Lung Tissue and Lavage Reveals Pathways that Link Responses in Allergen-Challenged Mice

The paper integrates proteomes from lung tissue and BALF in allergen-challenged mice to identify compartment-specific and shared biological pathways involved in allergic asthma responses.