Tryptophan Chemistry Driven by a Widespread Cytochrome P422 Enzyme Family
Wencheng Ma, Qian Wang, Qingyu Yang, Zhaojie Teng, Xiao Han, Moli Sang, Qiuyu Li, Ruili Wang, Peiyuan Feng, Jingyi Zhong, Yan Zhang, Yifeng Wei, Li Jiang, Frederick Peter Guengerich, Wei Zhang
The paper identifies a widespread cytochrome P422 enzyme family that performs four novel tryptophan transformations, revealing new enzymatic capabilities and introducing a computational tool for HBP discovery.
bioRxiv · Dec 13, 2025 · PreprintBiochemistry