Psychedelics relax predictive processing in the post-acute period by remodeling cortico-cortical feedback circuits
Chloe L. West, Fumiyasu Imai, Georgia Bastos, Molly A. Hornick, Lital Rachmany, Annabel Duran, Samen Nadeem, David Ricci, Anna M. Rader Groves, Joseph A. Wargo, Neil Van Leeuwen, Henry Sershen, K. Yaragudri Vinod, Darcy S. Peterka, Jordan P. Hamm
This study shows that psychedelics reduce predictive processing by weakening top-down cortical feedback circuits, an effect observed in both humans and mice.
bioRxiv · Jul 3, 2024 · PreprintNeuroscience