Darcy S. Peterka

This study shows how reinforcement learning modifies specific dendritic activity through synaptic plasticity, leading to the formation of task-relevant synaptic ensembles.

The paper shows that shared striatal neurons adapt their dynamics to support both internally and externally driven actions through context-specific changes in neural activity.

The paper shows that recurrent connectivity in hippocampal CA3 subregions shapes spatial coding strategies, with proximal neurons showing stable representations and distal neurons showing dynamic, context-specific activity.

This study identifies and manipulates striatal ensembles to show they control fine motor actions in real time.

The paper improves three-photon imaging for neuronal activity detection in behaving mice by reducing noise and increasing imaging speed.

The paper reveals the external globus pallidus (GPe) as a basal ganglia output hub with distinct subpopulations that mediate specific behaviors through projection-specific circuits.

The paper shows that global context rapidly modulates neural responses in V1, with global deviations eliciting enhanced responses and requiring feedback from ACa.

This study shows that ALM reconfigures local circuits to route sensory input to motor output based on context, using contingency neurons that encode both context and choice.

This paper introduces a computational method to reduce off-target stimulation in two-photon holographic optogenetics by optimizing stimulation sites using adaptive non-negative basis function regression.

This study shows that dopamine release dynamics in the nucleus accumbens correlate with blood oxygenation responses during associative learning, revealing a link between dopamine signaling and brain-wide plasticity.

The paper generates and characterizes knock-in mouse lines for precise genetic targeting of striatal and dopaminergic neurons, confirming their utility for studying neural circuits and disorders.

This study investigates how mTOR inhibition reverses glioma-induced changes in excitatory neurons, showing effects on mRNA, dendritic spines, and neuronal activity.

This study shows that psychedelics reduce predictive processing by weakening top-down cortical feedback circuits, an effect observed in both humans and mice.

This protocol provides standardised measurements to assess and compare multiphoton microscope performance across users.

maskNMF improves demixing of dense calcium imaging data by denoising, sparsening, and using constrained non-negative matrix factorization to accurately recover neural activity.

The paper investigates how interregional synchrony in the theta/alpha band supports deviance detection in visual processing by modulating V1 interneurons.

This study shows prolonged anesthesia in mice leads to cognitive impairment and altered synaptic turnover in the cortex, with increased synapse formation during anesthesia and loss afterward.

The paper identifies an amygdala circuit that mediates experience-dependent momentary exploratory arrests in mice without affecting place preference or anxiety-like behaviors.

The paper uses in-vivo two-photon calcium imaging to show that seizures begin as silent microseizures in neuronal ensembles before becoming detectable by LFP.

The paper demonstrates a holographic system for 3D two-photon stimulation and imaging of neural activity in the mouse neocortex in vivo with cellular resolution.

The paper introduces multi-scale approaches to improve imaging and analysis of large neuronal populations by decimating spatial and temporal resolution to enable faster imaging or larger field of view with minimal accuracy loss.