Machine Learning-Assisted Pathway Optimization in Large Combinatorial Design Spaces: a p-Coumaric Acid Case Study
Thomas Abeel, Paul van Lent, Rianne van der Hoek, Joep P. J. Schmitz, Sara Moreno Paz, Irsan Kooi, Moniek Jonkers, Priscilla Zwartjens
This paper applies a machine learning-assisted recommendation strategy with exploration-exploitation balance to optimize p-coumaric acid production in yeast, achieving a 137% increase over parent strains.
bioRxiv · Jun 13, 2025 · PreprintBioengineering