Fibroblasts sense spatial proximity via an EGFR CREB5 axis to restore quiescent synovial lining in remission rheumatoid arthritis
Sonia Presti, Ksenia S. Anufrieva, Ce Gao, Sean A Prell, Kartik Bhamidipati, Vikram Khedgikar, PHILIP E. BLAZAR, Jeffrey K. Lange, Morgan H Jones, Michael B. Brenner, Ellen M. Gravallese, Ilya Korsunsky, Mihir D. Wechalekar, Shideh Kazerounian, Kevin S. Wei
The paper identifies a spatial proximity-sensing mechanism in fibroblasts that restores quiescent synovial lining during RA remission through the EGFR-CREB5 axis.
bioRxiv · Dec 12, 2025 · PreprintGenomics