Author

Vikram Khedgikar

Brigham and Women's Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Developmental Biology· 1 Genomics· 1 Immunology· 1 Molecular Biology· 1

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Research Focus:differential expression· 3 Approach:experimental assay· 3 Organism:human· 3 Assay:spatial transcriptomics· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Ce GaoiD· 3 shared Ellen M. GravalleseiD· 3 shared Jeffrey K. LangeiD· 3 shared Kartik Bhamidipati· 3 shared Kevin S. WeiiD· 3 shared Mihir D. WechalekariD· 3 shared PHILIP E. BLAZARiD· 3 shared Shideh Kazerounian· 3 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersMolecular Biology

Ce GaoORCID

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Author profile →

4 papers

Recent·Most cited

Fibroblasts neurotrophin signaling sustains pathological vascular maturation in rheumatoid arthritis.

Vikram Khedgikar, Qian Qin, Miles Tran, Shideh Kazerounian, Ce Gao, Sean A. Prell, Alexa B. R. McIntyre, Kartik Bhamidipati, Sonia Presti, PHILIP E. BLAZAR, Jeffrey K. Lange, Morgan Jones, Ellen M. Gravallese, Mihir D. Wechalekar, Kevin Wei

The paper identifies fibroblast-derived neurotrophin signaling as a driver of abnormal vascular maturation in RA synovia and shows that neurotrophin inhibitors can reverse this process.

bioRxiv · Mar 15, 2026 · PreprintMolecular Biology

Spatial patterning of fibroblast TGFβ signaling underlies treatment resistance in rheumatoid arthritis

Kartik Bhamidipati, Alexa B. R. McIntyre, Shideh Kazerounian, Ce Gao, Soon Wei Wong, Miles Tran, Sean A. Prell, Rachel Lau, Vikram Khedgikar, Christopher Altmann, Annabelle Small, Roopa Madhu, Sonia Presti, Ksenia S. Anufrieva, PHILIP E. BLAZAR, , Kevin Wei

Perivascular COMPhi fibrogenic fibroblasts expand in treatment-refractory rheumatoid arthritis synovium, where endothelial Notch signaling patterns fibroblast TGF-beta sensitivity via TGFBR3 regulation and persists despite post-treatment immune cell depletion.

Nature Immunology · Jan 15, 2026Peer-reviewedImmunology✦ In-depth digest

Fibroblasts sense spatial proximity via an EGFR CREB5 axis to restore quiescent synovial lining in remission rheumatoid arthritis

Sonia Presti, Ksenia S. Anufrieva, Ce Gao, Sean A Prell, Kartik Bhamidipati, Vikram Khedgikar, PHILIP E. BLAZAR, Jeffrey K. Lange, Morgan H Jones, Michael B. Brenner, Ellen M. Gravallese, Ilya Korsunsky, Mihir D. Wechalekar, Shideh Kazerounian, Kevin S. Wei

The paper identifies a spatial proximity-sensing mechanism in fibroblasts that restores quiescent synovial lining during RA remission through the EGFR-CREB5 axis.

bioRxiv · Dec 12, 2025 · PreprintGenomics

LGR6 is necessary for attaining peak bone mass and regulates osteogenesis through differential ligand use

Vikram Khedgikar, Julia F. Charles, Jessica A. Lehoczky

This study shows LGR6 is essential for osteoblast proliferation, differentiation, and peak bone mass, with distinct signaling roles for its ligands RSPO2 and MaR1.

Bone · Nov 30, 2021Peer-reviewedDevelopmental Biology