Ce Gao

Plasma Proteomic Profiling Identifies a Subset of HIV Elite Controllers with Inflammatory Profiles Resembling People Without HIV

The paper identifies a subset of HIV elite controllers with proteomic profiles similar to uninfected individuals, associated with lower viral reservoirs and protective HLA alleles.

Spatial Transcriptomics Identifies Immune-Stromal Niches Associated with Cancer in Adult Dermatomyositis

This study uses spatial and single-cell transcriptomics to identify immune-stromal niches in adult-onset dermatomyositis, revealing distinct cellular and cytokine signatures associated with cancer and non-cancer lesions.

SPP1hi macrophages in fibrin niches promote hyperplastic tissue remodeling in rheumatoid arthritis synovium

SPP1hi macrophages in RA synovial fibrin deposits promote tissue hyperplasia.

Fibroblasts neurotrophin signaling sustains pathological vascular maturation in rheumatoid arthritis.

The paper identifies fibroblast-derived neurotrophin signaling as a driver of abnormal vascular maturation in RA synovia and shows that neurotrophin inhibitors can reverse this process.

Spatial patterning of fibroblast TGFβ signaling underlies treatment resistance in rheumatoid arthritis

Perivascular COMPhi fibrogenic fibroblasts expand in treatment-refractory rheumatoid arthritis synovium, where endothelial Notch signaling patterns fibroblast TGF-beta sensitivity via TGFBR3 regulation and persists despite post-treatment immune cell depletion.

Fibroblasts sense spatial proximity via an EGFR CREB5 axis to restore quiescent synovial lining in remission rheumatoid arthritis

The paper identifies a spatial proximity-sensing mechanism in fibroblasts that restores quiescent synovial lining during RA remission through the EGFR-CREB5 axis.

Spatial Transcriptomics Identify T Cell-Driven Mechanisms of Kidney Damage in Immune Checkpoint Inhibitor-Associated Acute Interstitial Nephritis

This study uses spatial transcriptomics to identify CD8+ T cell-driven mechanisms of kidney damage in ICI-AIN, showing increased IFN-γ signaling and proinflammatory myeloid cell activation.

Chronic sensing of host-derived lipids is an all-in-one signal that primes and activates NLRP3.

The paper shows that chronic exposure to oxidized phospholipids primes and activates NLRP3 via NRF2, independent of microbial cues, contributing to atherogenesis.

Lactate transport inhibition therapeutically reprograms fibroblast metabolism in experimental pulmonary fibrosis

The paper shows that inhibiting lactate transporters MCT1 and MCT4 reduces myofibroblast differentiation and pulmonary fibrosis in vitro and in vivo.

Zebrafish hhex null mutant develops an intrahepatic intestinal tube due to de-repression of cdx1b and pdx1

This study shows that zebrafish hhex-null mutants develop an intrahepatic intestinal tube due to de-repression of cdx1b and pdx1, which replaces the normal hepatopancreatic duct system.