A human mitochondrial isoform of TRPV1 regulates intracellular Ca2+ simultaneously with mitochondrial thermolysis
Florian Beignon, Sylvie Ducreux, Léa Tuifua, Yannick Le Dantec, Morgane Le Mao, David Goudenège, Arnaud Chevrollier, Salim Khiati, Hélène Tricoire-Leignel, Naïg Guéguen, César Mattei, Guy Lenaers
The paper identifies a mitochondrial TRPV1 isoform, mitoTRPV1, which regulates intracellular Ca2+ and mitochondrial temperature without affecting respiration.
bioRxiv · Sep 25, 2024 · PreprintCell Biology