Guy Lenaers

G-quadruplex ligand RHPS4 compromises cellular radio-resistance by blocking the increase in mitochondrial mass and activity induced by ionising irradiation.

This study shows that the G-quadruplex ligand RHPS4 reduces radioresistance by inhibiting mitochondrial adaptations caused by ionising irradiation.

Altered endothelial mitochondrial Opa1-related fusion in mouse amplifies age-associated vascular and kidney damages

This study shows that reduced Opa1 in endothelial cells of old mice worsens vascular function and increases kidney oxidative stress.

A human mitochondrial isoform of TRPV1 regulates intracellular Ca2+ simultaneously with mitochondrial thermolysis

The paper identifies a mitochondrial TRPV1 isoform, mitoTRPV1, which regulates intracellular Ca2+ and mitochondrial temperature without affecting respiration.

In-depth study of MPV17: a molecular travel unveiling a mitochondrial calcium regulation function

This study identifies MPV17 as a regulator of mitochondrial calcium and oxidative stress, showing its role in preventing mtDNA degradation through interactions with the MICOS complex.

Physiology and function of PNS axons rely on glycolic metabolism in myelinating Schwann cells

This study shows that lactate production via aerobic glycolysis in myelinating Schwann cells is essential for maintaining peripheral nerve axon physiology and function.