Effective targeting of CD19 positive primary B-ALL cells using CAR-NK cells generated with mRNA-LNPs
Hossein Salehi-Shadkami, Mosslim Sedghi, Shima Tavoosi, Masoumeh Alimohammadi, Reza Alimohammadi, Maryam Barkhordar, Ahmadreza Mofayezi, Mohammad Sadra Modaresi, Mohammad Vaezi, Somaye Dehghanizadeh, Mohammad Ahmadvand, Vahid Khoddami
This study develops anti-CD19 CAR-NK cells using mRNA-LNPs, showing enhanced cytotoxicity against CD19+ B-cell malignancies.
Current Research in Translational Medicine · Dec 17, 2025Peer-reviewedCancer Biology