CK2α phosphorylates CHIP for oncogenesis: A novel post-translational switch in cancer
Subhajit Karmakar, Mouli Chatterjee, Malini Basu, Mrinal K. Ghosh
This paper identifies CK2α as a kinase that phosphorylates CHIP, promoting its degradation and oncogenesis, and shows that CK2 inhibition restores CHIP function and suppresses tumor growth.
bioRxiv · Oct 15, 2025 · PreprintCancer Biology