Tracing the function expansion for a primordial protein fold in the era of fold-based function prediction: beta-trefoil
Moushmi Goswami, Subhashini Srinivasan
This study uses fold-fold comparison to identify proteins with beta-trefoil fold across 32 functional classes, showing its utility in function prediction beyond sequence-based methods.
PLoS ONE · Jul 3, 2025Peer-reviewedBioinformatics