Proteostasis Associated Variants in HSPB5 Destabilize the αB-crystallin Domain
Mst. Shanzeda Khatun, Md. Chayan Ali, Largess Barua, Yeasmin Akter Munni, Raju Dash, Md. Mafizur Rahman
This study identifies three deleterious SNPs in HSPB5 that disrupt the αB-crystallin domain's structure and function, contributing to proteotoxicity-related diseases.
bioRxiv · Nov 12, 2024 · PreprintBioinformatics