Mitoxantrone Hydrochloride Targets APP and LRRK2 to Improve Neurodegeneration in Parkinson's Models
Haitao Tu, Zhi-Wei Zhang, Chaitanya Kumar Jaladanki, Muhammad Yaaseen Gulam, Wuan Ting Saw, Sook Yoong Chia, Yinxia Chao, Zhidong Zhou, Zhong Pei, Hao Fan, Eng-King Tan, Li Zeng
This study identifies Mitoxantrone hydrochloride as a drug that targets APP and LRRK2 to improve neurodegeneration in Parkinson's disease models.
bioRxiv · Oct 6, 2025 · PreprintNeuroscience