Astrocytic Cathepsin D truncates α-synuclein and promotes Lewy neurite-like aggregation in neurons
Hiroshi Hanafusa, Kota Ohashi, Hiromu Shojima, Naoki Hisamoto, Takeshi Kameyama, Muneaki Miyata, Kiyohito Mizutani, Yoshimi Takai, Kunihiro Matsumoto
This study shows astrocytes process and propagate α-synuclein aggregates via lysosomal protease Cathepsin D, promoting Lewy neurite-like aggregation in neurons.
bioRxiv · Oct 3, 2025 · PreprintPathology