Redefining the topology of the human bone marrow using augmented spatial transcriptomic analysis
Rosalin A. Cooper, Emily Simon Thomas, Muhammad Dawood, Hosuk Ryou, Anna M. Sozanska, Carlo Pescia, Oliver McCallion, Muskaan Gupta, Renuka Teague, Joanna Hester, Fadi Issa, Dan J. Woodcock, Bethan Psaila, Adam J. Mead, Jens Rittscher, Daniel J. Royston
This study uses spatial transcriptomic analysis and machine learning to redefine the topology of human bone marrow in health and myeloproliferative neoplasms, revealing new insights into cellular heterogeneity and fibrosis.
bioRxiv · Dec 23, 2025 · PreprintCancer Biology