Metal-organic framework (MOF) nanomedicine preparations of sildenafil designed for the future treatment of pulmonary arterial hypertension
N. A. Mohamed, H. Abou Saleh, Y. Kameno, I. Marei, G. de Nucci, B. Ahmetaj-Shala, F. Shala, N. S. Kirkby, L. Jennings, R. P. Davies, P. D. Lickiss, J. A. Mitchell
This paper develops a nanomedicine formulation of sildenafil using MIL-89 MOF for controlled release in PAH treatment, showing delayed vasodilation.
bioRxiv · Jul 30, 2019 · PreprintPharmacology & Toxicology