Regioselective control of biocatalytic C-H activation and halogenation
E. N. Kissman, M. E. Neugebauer, K. H. Sumida, C. V. Swenson, N. A. Sambold, J. A. Marchand, D. C. Millar, M. C. Y. Chang
The paper investigates the selectivity mechanisms of halogenases HalB and HalD, revealing how substrate-lid positioning enables regioselective chlorination of lysine and ornithine.
bioRxiv · Aug 4, 2022 · PreprintBiochemistry