Author

K. H. Sumida

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:protein design· 2 Assay:protein sequence· 2 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

D. Baker· 2 shared A. K. Bera· 1 shared A. Kang· 1 shared B. I. M. Wicky· 1 shared B. R. King· 1 shared B. Sankaran· 1 shared C. V. Swenson· 1 shared D. C. Millar· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersBiochemistry

D. Baker

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3 papers

Recent·Most cited

Computational stabilization of a non-heme iron enzyme enables efficient evolution of new function

B. R. King, K. H. Sumida, J. L. Caruso, D. Baker, J. G. Zalatan

The paper uses ProteinMPNN to stabilize Fe(II)/KG enzymes, enabling more effective directed evolution of new catalytic functions.

bioRxiv · Apr 18, 2024Biochemistry

Improving protein expression, stability, and function with ProteinMPNN

K. H. Sumida, R. Nunez Franco, I. Kalvet, S. J. Pellock, B. I. M. Wicky, L. F. Milles, J. Dauparas, J. Wang, Y. Kipnis, N. Jameson, A. Kang, J. De La Cruz, B. Sankaran, A. K. Bera, G. Jimenez Oses, D. Baker

This paper introduces ProteinMPNN, a deep learning model that improves protein expression, stability, and function by incorporating evolutionary and structural information.

bioRxiv · Oct 3, 2023Biochemistry

Regioselective control of biocatalytic C-H activation and halogenation

E. N. Kissman, M. E. Neugebauer, K. H. Sumida, C. V. Swenson, N. A. Sambold, J. A. Marchand, D. C. Millar, M. C. Y. Chang

The paper investigates the selectivity mechanisms of halogenases HalB and HalD, revealing how substrate-lid positioning enables regioselective chlorination of lysine and ornithine.

bioRxiv · Aug 4, 2022 · PreprintBiochemistry