The meta-epigenomic structure of purified human stem cell populations is defined at cis-regulatory sequences
N. Ari Wijetunga, Fabien Delahaye, Yong Mei Zhao, Aaron Golden, Jessica C Mar, Francine H. Einstein, John M. Greally
The paper analyzes DNA methylation variability in purified human CD34+ HSPCs and finds increased variability at candidate enhancers and genes involved in lineage commitment, suggesting meta-epigenomic approaches can reveal cell subtype heterogeneity.
Nature Communications · Oct 20, 2014Peer-reviewedGenomics