Fabien Delahaye

This study shows that maternal high-fat diet during lactation accelerates tauopathy in THY-Tau22 mice, with sex-dependent effects where males are more affected earlier than females.

This study shows BIN1 regulates L-type calcium channels in neurons, affecting calcium homeostasis and electrical activity, and links these changes to Alzheimer's disease pathology.

This study shows that BIN1 isoform1 causes early endosome defects and neurodegeneration in Drosophila and human neurons, linking it to Alzheimer's disease pathology.

The paper links DNA methylation changes in HSCs from large for gestational age neonates to altered quiescence via transcriptional network disruption.

The paper investigates how genetic variants affect gene expression and DNA methylation in human placentas, revealing interaction profiles and providing a reference for future studies.

The paper analyzes DNA methylation variability in purified human CD34+ HSPCs and finds increased variability at candidate enhancers and genes involved in lineage commitment, suggesting meta-epigenomic approaches can reveal cell subtype heterogeneity.

This study examines how extreme fetal growth affects epigenetic changes in stem cells, revealing sexual dimorphism in these responses and their potential implications for adult disease risk.