Aaron Golden

The paper examines the association between genomic instability, measured by copy number alterations, and survival outcomes in luminal breast cancers, finding that higher CNA burden correlates with poorer survival in luminal A grade 3 tumors.

AptCompare identifies RNA aptamer motifs from HTS-SELEX data by integrating six algorithms and ranking candidates based on binding affinity validation.

The paper identifies RNA:DNA hybrids in the human genome, showing they are purine-rich, associated with hypomethylation and heterochromatin domains, and bound by ILF2/ILF3 transcription factors.

The paper analyzes DNA methylation variability in purified human CD34+ HSPCs and finds increased variability at candidate enhancers and genes involved in lineage commitment, suggesting meta-epigenomic approaches can reveal cell subtype heterogeneity.