Loss of Activating Transcription Factor 3 prevents KRAS-mediated pancreatic cancer
N. Azizi, J. Toma, M. Martin, M. F. Khalid, N. Steele, J. Shi, M. Pasca Di Magliano, C. L. Pin
This study shows that loss of ATF3 reduces pancreatic cancer progression by limiting acinar-to-ductal metaplasia and enhancing regeneration, but KRASG12D can bypass ATF3's requirement in some contexts.
bioRxiv · Mar 27, 2020Cancer Biology