Conserved residues in the extracellular loop 2 regulate Stachel-mediated activation of ADGRG2
A. A. Gad, P. Azimzadeh, N. Balenga
This study identifies conserved residues in ECL2 of ADGRG2 that are critical for Stachel-mediated activation and surface expression, revealing their role in signaling and degradation.
bioRxiv · Feb 14, 2021Pharmacology & Toxicology