MAIT cells activate dendritic cells to promote T follicular helper cell differentiation and humoral immunity
T. E. Pankhurst, K. H. Buick, J. L. Lange, A. J. Marshall, K. R. Button, O. R. Palmer, K. J. Farrand, I. F. N. Stewart, T. Bird, N. C. Mason, B. J. Compton, D. Comoletti, M. Salio, G. F. Painter, I. F. Hermans, L. M. Connor
This study shows that MAIT cells can act as adjuvants in mucosal vaccines by activating dendritic cells and promoting T follicular helper cell differentiation and IgA production.
bioRxiv · Mar 31, 2022 · PreprintImmunology