Single-cell chromatin profiling reveals demethylation-dependent metabolic vulnerabilities of breast cancer epigenome
M. Kusi, M. Zand, C.-L. Lin, C.-M. Wang, N. D. Lucio, N. B. Kirma, J. Ruan, T. H.- M. Huang, K. Mitsuya
This study uses scATAC-seq to show 2HG enantiomers disrupt DNA and histone demethylation, leading to epigenetic changes in breast cancer cells.
Cell Reports · Jan 1, 2022Peer-reviewedCancer Biology