A freeze-and-thaw induced-fragment of the microtubule-associated protein Tau in rat brain extracts: implications for the biochemical assessment of neurotoxicity
I. C. Vasconcelos, R. M. d. Campos, H. M. K. Schwaemmle, A. P. Masson, G. D. Ferrari, L. C. Alberici, V. M. Faca, N. Garcia-Cairasco, A. S. Sebollela
This study shows that freeze-and-thaw cycles cause Tau fragmentation in rodent brain extracts, affecting WB results, but not in human samples.
bioRxiv · Nov 16, 2020Biochemistry