The AIRE G228W mutation disturbs the interaction of AIRE with its partner molecule SIRT1
J. C. Santos, M. Dametto, A. P. Masson, V. M. Faca, R. Bonacin, E. A. Donadi, G. A. Passos
This study investigates how the AIRE G228W mutation disrupts the AIRE-SIRT1 interaction, affecting transcriptional processes in medullary thymic epithelial cells.
bioRxiv · Aug 24, 2021Immunology