Macrophage Depletion Protects Against Cisplatin-Induced Ototoxicity and Nephrotoxicity
C. Y. W. Sung, N. Hayase, P. S. T. Yuen, J. Lee, K. Fernandez, X. Hu, H. Cheng, R. A. Star, M. E. Warchol, L. L. Cunningham
This study shows that eliminating macrophages with PLX3397 reduces cisplatin-induced hearing and kidney damage by limiting platinum accumulation.
bioRxiv · Nov 16, 2023Immunology