Immuno-Responsive Gene-1: The Mitochondrial Key to Th17 Cell Pathogenicity in CNS Autoimmunity
M. Nematullah, M. Fatma, G. Zhou, F. Rashid, K. Ayasolla, M. E. Ahmed, M. Sajad, I. Zahoor, N. Hoda, R. Rattan, s. Giri
This study identifies Irg1 as a protective gene that negatively regulates pathogenic Th17 cells in CNS autoimmunity using knockout mice and single-cell RNA sequencing.
bioRxiv · Dec 24, 2023 · PreprintImmunology