G. Zhou

PLINDER: The protein-ligand interactions dataset and evaluation resource

PLINDER provides a large, annotated PLI dataset with diverse annotations and improved evaluation splits to better assess computational methods for drug design.

Host-derived Interleukin 1α induces an immunosuppressive tumor microenvironment via regulating monocyte-to-macrophage differentiation

This study shows that host-derived IL-1α promotes an immunosuppressive tumor microenvironment by regulating monocyte-to-macrophage differentiation in breast cancer.

Observing one-divalent-metal-ion dependent and histidine-promoted His-Me family I-PpoI nuclease catalysis in crystallo

This study uses time-resolved crystallography to investigate the catalytic mechanism of His-Me family I-PpoI nuclease, revealing the role of a single divalent metal ion and histidine in DNA hydrolysis.

Towards high-resolution modeling of small molecule-ion channel interactions

This study evaluates two ligand docking methods for ion channel complexes, finding they can sample near-native poses but struggle to consistently identify them as top-scoring models.

An artificial intelligence accelerated virtual screening platform for drug discovery

The paper develops RosettaVS, an AI-accelerated virtual screening platform that identifies drug candidates with high binding affinity across two targets, achieving a 14% and 44% hit rate in under seven days.

Immuno-Responsive Gene-1: The Mitochondrial Key to Th17 Cell Pathogenicity in CNS Autoimmunity

This study identifies Irg1 as a protective gene that negatively regulates pathogenic Th17 cells in CNS autoimmunity using knockout mice and single-cell RNA sequencing.

Molecular mechanism of NAD+ binding to the Nudix homology domains of DBC1

This study investigates how NAD+ binds to DBC1's Nudix homology domains using NMR, ITC, and molecular docking, revealing key residues and binding affinity.

Controlling pericellular oxygen tension in cell culture reveals distinct breast cancer responses to low oxygen tensions

This study shows that controlling incubator gas phase O2 is insufficient to control pericellular O2 in cell culture, revealing non-monotonic breast cancer responses to low O2.

Single-chain fluorescent integrators for mapping G-protein-coupled receptor agonists

The paper introduces SPOTIT and SPOTall sensors to detect GPCR agonist localization in the whole brain using fluorescent integrator sensors for multiple neuromodulators.

A Novel Pan-RAS Inhibitor with a Unique Mechanism of Action Blocks Tumor Growth in Mouse Models of GI Cancer

This paper introduces ADT-007, a novel pan-RAS inhibitor that effectively blocks tumor growth in mouse models of GI cancer by targeting RAS activation and inducing apoptosis.

Multimodal engineering of extracellular vesicles for efficient intracellular protein delivery

This paper develops VEDIC and VFIC systems for efficient intracellular protein delivery using engineered extracellular vesicles, achieving high recombination and genome editing efficiency in vitro and in vivo.

Tension sensing by FAK governs nuclear mechanotransduction, endothelial transcriptome and fate

This study shows that FAK-mediated tension sensing in endothelial cells regulates nuclear mechanotransduction, transcriptome, and cell fate, crucial for maintaining a restrictive endothelial barrier.

Melanin enhances metastatic melanoma colonization by inhibiting ferroptosis

This study shows melanin protects melanoma cells from ferroptosis, enhancing metastasis, and suggests targeting melanin and ferroptosis could improve treatment of metastatic melanoma.

Novel endogenous engineering platform for robust loading and delivery of functional mRNA by extracellular vesicles

This paper develops an mRNA delivery system using extracellular vesicles engineered with RNA-binding domains and fusogenic moieties, showing improved efficacy in a melanoma model.

Single-Cell Map of Dynamic Multicellular Ecosystem of Radiation-Induced Intestinal Injury

This study maps the dynamic multicellular ecosystem of radiation-induced intestinal injury using single-cell RNA sequencing, revealing heterogeneous radiosensitivities and cellular interactions.

Cyclic peptide structure prediction and design using AlphaFold

This paper modifies AlphaFold to predict and design cyclic peptides, achieving high accuracy in structure prediction and de novo design with experimental validation.

Latitude influences stability via stabilizing mechanisms in naturally-assembled forest ecosystems at different spatial grains

The paper examines how latitude affects ecosystem stability in forests across different spatial scales, finding that species asynchrony and stability play key roles, with latitude influencing these mechanisms to counteract species richness effects.

Mapping potential malaria vector larval habitats for larval source management: Introduction to multi-model ensembling approaches

This paper introduces a framework for multi-model ensemble modeling to predict malaria vector larval habitats, finding that ensembled models improve prediction accuracy by 20% compared to individual models.

Kinetic and Structural Analysis of Ribonucleotide Extension by DNA Polymerase η

This study investigates how DNA polymerase η extends ribonucleotide-terminated primers, showing reduced fidelity and structural changes during extension.

MAM-STAT3-induced upregulation of mitochondrial Ca+2 causes immunosenescence in patients with type A mandibuloacral dysplasia

This study identifies mitochondrial Ca+2 dysregulation via MAM-STAT3 as a driver of immunosenescence in type A mandibuloacral dysplasia.

Automatic and accurate ligand structure determination guided by cryo-electron microscopy maps

This paper develops a tool to automatically determine ligand structures from cryoEM maps and evaluates its accuracy across EMDB data.

Flavivirus prM interacts with MDA5 and MAVS to inhibit RLR antiviral signaling

This study identifies how flavivirus prM proteins interact with MDA5 and MAVS to inhibit RLR antiviral signaling, revealing species-dependent immune evasion mechanisms.

Sex-specific transcription and DNA methylation landscapes of the Asian citrus psyllid, a vector of huanglongbing pathogens.

The paper identifies the X chromosome of the Asian citrus psyllid and compares transcription and DNA methylation between male and female adults, finding sex-specific patterns and no direct link between methylation and gene expression.

Comparative analysis of cattle breeds as satellite cell donors for cultured beef

The paper compares SC proliferation and differentiation across cattle breeds to identify optimal donors for cultured beef production.

Effect of gastrointestinal alterations mimicking elderly conditions on in vitro digestion of meat and soy proteins

This study evaluates how in vitro digestion of meat and soy proteins differs under gastrointestinal conditions mimicking elderly achlorhydria compared to adults, showing reduced hydrolysis and distinct protein degradation patterns in elderly conditions.

Emerging mosquito resistance to piperonyl butoxide-synergized pyrethroid insecticide and its mechanism

This study examines mosquito resistance to PBO-synergized pyrethroids and finds that field mosquitoes are resistant despite PBO exposure, due to elevated metabolic enzyme levels and knockdown resistance mutations.

Larval ecology and bionomics of Anopheles funestus in highland and lowland sites in western Kenya

This study examines the larval ecology and sporozoite infection rates of Anopheles funestus in highland and lowland sites in western Kenya, finding that man-made ponds are most abundant for larvae and proximity to houses is a key environmental factor.

Effects of Guangzhou seasonal climate change on the development of Aedes albopictus and its susceptibility to DENV-2

This study examines how seasonal climate changes in Guangzhou affect Aedes albopictus development and its susceptibility to DENV-2, finding that mosquitoes can still transmit the virus in winter.

Tumor PD-L1 selectively suppresses type I interferon in myeloid cells to suppress CTL recruitment to promote lung metastasis

Learning a force field from small-molecule crystal lattice predictions enables consistent sub-Angstrom protein-ligand docking

The paper improves protein-ligand docking by optimizing force field parameters using small-molecule crystal structures, achieving better binding structure prediction.