2019-20 H1N1 clade A5a.1 viruses have better in vitro replication compared with the co-circulating A5a.2 clade
N. J. Swanson, P. Marinho, A. Dziedzic, A. Jedlicka, H. Liu, K. Fenstermacher, R. E. Rothman, A. Pekosz
The paper compares antigenic drift and viral fitness between two H1N1 clades, A5a.1 and A5a.2, finding that A5a.2 had reduced viral fitness despite similar or greater antigenic drift.
bioRxiv · Feb 26, 2023 · PreprintMicrobiology