N. Kirstein

Human ORC/MCM density is low in active genes and correlates with replication time but does not solely define replication initiation zones

The paper examines ORC/MCM density in relation to replication timing and initiation zones, finding no direct correlation with initiation but a link to replication timing.

Active transcription regulates ORC/MCM distribution whereas replication timing correlates with ORC density in human cells

The paper compares ChIP-seq profiles of ORC and MCM proteins with replication timing to show that active transcription affects ORC/MCM distribution and replication timing correlates with ORC density in human cells.