S. Krebs

Traitor-virus-guided discovery of novel antiviral factors

This study uses HIV-guided CRISPR to identify antiviral factors by analyzing sgRNA enrichment during viral replication.

Gene Therapy for Cardiomyopathy associated with Duchenne Muscular Dystrophy in a Pig Model

This study shows that AAV1.SERCA2a gene therapy improves heart function and reduces arrhythmia in a pig model of Duchenne muscular dystrophy.

Increased pulmonary monocyte infiltration and attenuated phagocytosis defines perinatal dysfunction of innate immunity in Cystic Fibrosis

The paper identifies increased monocyte infiltration and reduced phagocytosis in CF lungs at birth, suggesting innate immune dysfunction and the need for early treatment.

The highly and perpetually upregulated thyroglobulin gene is a hallmark of functional thyrocytes

The paper identifies thyroglobulin gene (Tg) as a permanently upregulated gene in thyrocytes across vertebrates, providing insights into mechanisms of sustained transcriptional activation.

German Ixodes inopinatus samples may not actually represent this tick species

The study shows that German ticks morphologically identified as Ixodes inopinatus are genetically Ixodes ricinus, not I. inopinatus, and mitochondrial data alone cannot distinguish between the two species.

Sequence Dependent UV Damage of Complete Pools of Oligonucleotides

The paper quantifies UV damage susceptibility of all 4096 hexamer DNA sequences using high-throughput sequencing, revealing sequence context effects on lesion formation.

SARS-CoV-2 variants of concern are dependent on IFITM2 for efficient replication in human lung cells

The paper was withdrawn due to duplicate submission and is not intended for citation.

SARS-CoV-2 variants of concern remain dependent on IFITM2 for efficient replication in human lung cells

This study shows that SARS-CoV-2 variants of concern (VOCs) require IFITM2 for efficient replication in human lung cells, with IFITM2 depletion reducing viral RNA and infectious virus production by over four orders of magnitude.

The Delta variant of SARS-CoV-2 maintains high sensitivity to interferons in human lung cells

This study examines IFN sensitivity of SARS-CoV-2 variants, finding Delta remains as sensitive as early isolates, while Alpha, Beta, and Gamma show increased resistance.

Sex Differences in Brain Tumor Glutamine Metabolism Reveal Sex-Specific Vulnerabilities to Treatment

The paper identifies sex differences in glutamine metabolism in glioblastomas, showing male tumors have higher glutamine uptake and are more sensitive to GLS1 inhibition than female tumors.

Human ORC/MCM density is low in active genes and correlates with replication time but does not solely define replication initiation zones

The paper examines ORC/MCM density in relation to replication timing and initiation zones, finding no direct correlation with initiation but a link to replication timing.

HIV-1 Envelope and MPER antibody structures in lipid assemblies

This study presents methods to incorporate full-length HIV-1 Env into lipid assemblies for structural analysis, revealing the quaternary epitope of an MPER antibody and Env tilting during neutralization.

Active transcription regulates ORC/MCM distribution whereas replication timing correlates with ORC density in human cells

The paper compares ChIP-seq profiles of ORC and MCM proteins with replication timing to show that active transcription affects ORC/MCM distribution and replication timing correlates with ORC density in human cells.

Epstein-Barr virus inactivates the transcriptome and disrupts the chromatin architecture of its host cell in the first phase of lytic reactivation

This study shows that EBV lytic reactivation causes global chromatin remodeling and transcriptome disruption in host cells before viral DNA replication.

Antigen-specific T-cell receptor signatures of cytomegalovirus infection

The paper identifies CMV-specific TCRβ signatures as biomarkers for antiviral T-cell responses by analyzing TCRβ sequences from CMV-infected individuals.