In dystrophic mdx hindlimb muscles where fibrosis is limited versican haploinsufficiency transiently improves contractile function without decreasing inflammation
D. A. Debruin, N. L. McRae, A. B. Addinsall, D. R. McCulloch, R. G. Barker, A. Hayes, R. M. Murphy, N. Stupka
This study shows that reducing versican in dystrophic mdx hindlimb muscles improves contractile function in juvenile mice without reducing inflammation, but these benefits are lost in adults.
bioRxiv · May 7, 2024 · PreprintPhysiology