R. M. Murphy

In dystrophic mdx hindlimb muscles where fibrosis is limited versican haploinsufficiency transiently improves contractile function without decreasing inflammation

This study shows that reducing versican in dystrophic mdx hindlimb muscles improves contractile function in juvenile mice without reducing inflammation, but these benefits are lost in adults.

An in vitro model for vitamin A transport across the human blood-brain barrier

This study develops an in vitro model using iPSC-derived BMECs and vitamin A transport proteins to investigate retinol transport across the human BBB and identifies factors influencing its accumulation and permeation.

Gain-of-function genetic screen of the kinome reveals BRSK2 as an inhibitor of the NRF2 transcription factor

The paper identifies BRSK2 as a negative regulator of NRF2 by inhibiting protein synthesis through mTOR downregulation, suggesting it as a potential therapeutic target for NRF2-related diseases.

Repeated-ischaemic exercise enhances mitochondrial and ion transport gene adaptations in human skeletal muscle: Role of muscle redox state and AMPK

This study shows that repeated-ischaemic exercise increases mitochondrial and ion transport gene expression in human skeletal muscle, linked to oxidative stress and AMPK activation, but not hypoxia or lactate.

Post-exercise cold-water immersion increases Na+,K+-ATPase α2-isoform mRNA content in parallel with elevated Sp1 expression in human skeletal muscle

This study shows sprint-interval exercise increases NKA1 and β3 mRNA while decreasing β2 mRNA in human skeletal muscle, and post-exercise cold-water immersion increases NKA2 mRNA alongside Sp1 expression.