Allosteric regulation of glycogen phosphorylase solution phase structural dynamics at high spatial resolution
M. Kish, V. Smith, S. Subramanian, F. Vollmer, N. Lethbridge, N. Bond, L. Cole, J. J. Phillips
This study uses hydrogen/deuterium-exchange mass spectrometry to quantify solution phase structural dynamics of glycogen phosphorylase, revealing an entropic switch in the 280s loop that regulates substrate access.
bioRxiv · Jul 16, 2019 · PreprintBiophysics